Endocrine Abstracts

Context: Hyperandrogenemia in polycystic ovary syndrome (PCOS) represents a composite of raised serum concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEAS). In patients with PCOS, testosterone and androstenedione are primarily derived from the ovaries and DHEAS is a metabolite predominantly from the adrenals. It has been shown that atorvastatin reduces testosterone levels in patients with PCOS.Objective:...

Objective: We aim to study whether a difference exists in cardiovascular risk and variability of IR within the hyperandrogenic group of women with PCOS who are ovulatory and anovulatory.Method: Fifty-three women with PCOS were recruited. All subjects were diagnosed to have PCOS by the ESHRE/ASRM Rotterdam criteria where all patients had evidence of biochemical hyperandrogenism and hirsutism, chronic anovulation and polycystic ovaries on transvaginal ultr...

Aim: In chronic kidney disease (CKD) elevated aldosterone (Aldo) levels are a poor prognostic indicator, particularly in the context of a high dietary sodium intake, through unclear mechanisms. Blockade of the mineralocorticoid receptor (MR) improves surrogate patient outcomes. We hypothesised that regulation of aldosterone biosynthesis is disordered in CKD and aimed to compare this in a cohort of patients with CKD with subjects with essential hypertension (EH).<p class="a...

Objective: The individual changes in insulin sensitivity in response to exercise demonstrate a large variation. The mechanisms contributing to improved insulin sensitivity by training in type 2 diabetes are not fully known but presumably involve both metabolic and structural adaptations. The present study investigates if associations exist between changes in expression of key genes and improved insulin sensitivity, VO2max and glycemic control following exercise trai...

Pseudovitamin D deficiency rickets also called vitamin D-deficiency rickets type 1 (VDDR 1) is an autosomal recessive disorder in which 25-hydroxyvitamin D3 1 alpha-hydroxylase gene (CYP27B1) is deficient. VDDR1 is characterized by hypocalcemia,hypophosphatemia elevated serum PTH levels and low or undetectable serum concentrations of 1,25(OH)2D.We screened for mutations CYP27B1 in ten individuals from seven unrelated families wit...

Introduction: Ectopic parathyroid adenoma is a rare cause of primary hyperparathyroidism, it accounts for 10% of parathyroid adenomas.Observation: A 56 years old man with no past medical history developed sudden acute renal failure after few weeks of fatigability, polydypsia and emesis. Hypercalcemia of 4.20 mmol/l (2.2–2.5 mmol/l), serum creatinine of 306 mmol/l, hypophospatemia 0.72 mmol/l (0.80–1.5 mmol/l) and high alkaline phosphatase 205 I...

When it is limited the amount and quality of protein intake plays a role in determining the amount of skeletal muscle and the amount of essential amino acids (EAA) may be the primary determinant in this process. The purpose of this retrospective analysis was to examine the relationship between protein and EAA intake and the level of muscle mass in healthy omnivore (Om), vegan (Veg), and (OLV) Caucasian women. 21 Om, 22 OLV and 20 Veg were recruited. Women were sedentary, as as...

Introduction: The carcinoid heart disease is an uncommon valvular heart disease that may occur in carcinoid syndrome.Valvulopathy is reported in 50% to 70% of patients of carcinoid syndrome, due to the release of serotonin secreted by metastatic cells in the liver, reaching directly right side of heart. The left side is preserved because of inactivation of serotonin by lung parenchyma. Hypoxemia is an unusual presentation of the carcinoid heart disease.C...

Context: Acute lymphoblastic leukaemia (ALL) is the most common pediatric malignancy and its treatment includes many known risk factors for low bone mineral density (BMD), e.g. glucocorticosteroids, methotrexat and cranial radiotherapy (CRT).Objective: To evaluate bone mineral density (BMD) and markers of bone turn over in a group of adults with childhood onset ALL, treated with CRT and to evaluate the effect of 5 years with, and 8 years without GH thera...

Background: Menopause is associated to body composition transformations, such as an increase in total fat mass (obesity), central fat mass and a decrease in lean body mass (sarcopenia). Body fat distribution also changes with age, with an increase in visceral abdominal fat and a decrease in subcutaneous abdominal fat. Moreover, an increase in visceral fat may lead to increase the secretion of pro-inflammatory adipokines that further promote insulin resistance as well as potent...